pituitary function impairment after moderate traumatic brain injury

to determine the prevalence of pituitary hormone deficiencies after moderate traumatic brain injury (tbi). we conducted a prospective cohort and included 75 patients with moderate tbi with gcs between 9 and 13 who referred to emergency department of shariati hospital, tehran/iran, during 2004-2007. pituitary hormones were assessed 3 and 6 months after injury. in 3rd month post-injury, 39 cases had not any pituitary dysfunction; however, deficiencies in one, two and three of the pituitary hormones were found in 26, 8 and 2 patients, respectively. twenty one patients showed a deficiency in one of the pituitary hormones and only one case with deficiency of two after 6 months. the most prevalent changes occur in igf-1 and lh/fsh after moderate tbi. however, the whole deficiencies decrease over the time.